What is Pre-Syncope
Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope
Furlan, R. and Heusser, K. and Minonzio, M. and Shiffer, D. and Cairo, B. and Tank, J. and Jordan, J. and Diedrich, A. and Gauger, P. and Zamuner, Roberto, A . and Dipaola, F. and Porta, A. and Barbic, F. (2019) Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope. Journal of Clinical Medicine, 8 (9), page 1434. Multidisciplinary Digital Publishing Institute (MDPI). doi: 10.3390 / jcm8091434. ISSN 2077-0383.
|PDF - publisher's version (published version) |
Official URL: https://www.mdpi.com/2077-0383/8/9/1434
We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor unloading might promote orthostatic pre-syncope. Ten volunteers (32 ± 6 years) underwent electrocardiogram, beat-to-beat AP, respiratory activity and muscle sympathetic nerve activity (MSNA) recordings while supine (REST) and during 80 ° head-up tilt (HUT) followed by −10 mmHg stepwise increase of lower body negative pressure until pre-syncope. Cardiac and sympathetic baroreflex sensitivity were quantified. Spectrum analysis of systolic and diastolic AP (SAP and DAP) and calibrated MSNA (cMSNA) variability assessed the low frequency fluctuations (LF, ~ 0.1 Hz) of SAP, DAP and cMSNA variability. The squared coherence function (K2) quantified the coupling between cMSNA and DAP in the LF band. Analyzes were performed while supine, during asymptomatic HUT (T1) and at pre-syncope onset (T2). During T2 we found that: (1) sympathetic baroreceptor modulation was virtually abolished compared to T1; (2) a progressive decrease in AP was accompanied by a persistent but chaotic sympathetic firing; (3) coupling between cMSNA and AP series at 0.1 Hz was reduced compared to T1. A negligible sympathetic baroreceptor modulation during pre-syncope might disrupt sympathetic discharge pattern impairing the capability of vessels to constrict and promote pre-syncope.
|elib URL of the entry:||https://elib.dlr.de/129779/|
|Document type:||Journal contribution|
|Title:||Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope|
|Date:||10 September 2019|
|Published in:||Journal of Clinical Medicine|
|Gold Open Access:||Yes|
|In ISI Web of Science:||Yes|
|DOI:||10.3390 / jcm8091434|
|Side area:||Page 1434|
|Publishing company:||Multidisciplinary Digital Publishing Institute (MDPI)|
|Keywords:||syncope; vasovagal; baroreceptors; muscle sympathetic nerve activity; power spectrum analysis; heart rate variability; blood pressure variability; MSNA variability|
|HGF - research area:||Aviation, Space and Transportation|
|HGF program:||Space travel|
|HGF - program topic:||Research under space conditions|
|DLR - focus:||Space travel|
|DLR - research area:||R FR - research under space conditions|
|DLR - sub-area (project, plan):||R - System Physiology Project (old)|
|Institutes & facilities:||Institute for Aerospace Medicine|
Institute of Aerospace Medicine> Cardiovascular Aerospace Medicine
Institute for Aerospace Medicine> Head of ME
|Deposited by:||Schrage, Larissa|
|Deposited on:||29 Oct 2019 13:35|
|Last change:||31 Oct 2020 04:35|
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