What if 19

Covid-19: What happens when you combine corona vaccines?

There are still not enough corona vaccines, especially for the second vaccination. One possible solution: cheerfully combine funds from AstraZeneca, Biontech, Moderna and others. But while this is already happening in Germany, essential questions about the procedure remain unanswered. For example, whether this threatens unknown risks or side effects that have not yet been observed. But above all: do such combination vaccinations protect just as well as the previous procedure?

In theory, this mix & match is not a problem, say many experts, after all, the means do the same. One could think of Covid-19 vaccines as vehicles that transport cargo - the vehicles may be different and they may drop their cargo in different ways, but the cargo of spike proteins is the same, as Kylie Quinn of the Royal describes it Melbourne Institute of Technology. Since the freight is identical, the vaccines should theoretically work well together.

Maybe even better. Combining vaccines could even offer better protection against Covid-19 than taking the same agent twice, experts suspected in January based on a study on mice. To be flexible and to allow mixed vaccinations would therefore be associated with a low risk, but would offer the great opportunity to fully protect more people more quickly. The uncertainty speaks against it.

Because the vaccines are new and their combination has hardly been studied, there is little meaningful data so far. Now the first publications show that the combined vaccination may work. The Spanish CombiVacS study provided preliminary data that the immune response after the combination vaccination is at least as good as after the normal vaccination schedule. In addition, according to preliminary data from the Com-CoV study, people who first received the drug Vaxzevria from Oxford / AstraZeneca and then another got more frequent adverse reactions - but according to the study, these were only brief and generally harmless. / p>

Covid-19 vaccine mix: off into the unknown

For several months, those responsible for the Com-CoV vaccine study by the Oxford Vaccine Group have been testing various combinations of approved Covid-19 vaccines for the first and second vaccine dose. Most corona vaccinations require two stitches in the upper arm for optimal protection. While the first dose of the vaccine activates the immune system, the second - the booster - is supposed to increase its immune system and thus strengthen the effect.

The data of the current publication come from 830 people aged 50 years and older. The group examined four different combinations of primary and booster vaccine: a first dose of the Oxford / AstraZeneca vaccine, followed by a booster with either the Biontech / Pfizer vaccine or another dose of the Oxford / AstraZeneca vaccine, or a first Biontech Dose followed by a booster with either the Oxford / AstraZeneca vaccine or another dose of the Pfizer vaccine.